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Ipamorelin vs. Sermorelin: Which is Better?:  Although Ipamorelin and Sermorelin stimulate growth hormone production and share similar properties and results, they are very different in how they help patients achieve those goals. As a synthetic peptide, Ipamorelin can promote a massive increase in growth hormone for a short half-life of two hours. In contrast, sermorelin is a naturally occurring peptide with a half-life of 10-20 minutes but slowly releases HGH to last longer in the body. However, unlike Sermorelin, Ipamorelin doesn’t elevate cortisol production, which can cause unwanted side effects such as increased appetite. In addition, Ipamorelin differs significantly from Sermorelin as it also reduces somatostatin, the hormone that inhibits GH from reaching normal levels. With these added benefits, Ipamorelin is deemed more effective than Sermorelin in increasing growth hormone production for certain patients.