Manufacturing pharmaceuticals can be a difficult and time-consuming process. The complexity of today’s FDA and GMP regulations coupled with the steep costs associated with creating a new formulation or testing a potential manufacturing process often results in companies rethinking their approach to manufacturing pharmaceuticals and instead opting for a more cost-effective, less stringent alternative. One such alternative is sub-micron encapsulation technology (SME) which, as the name suggests, involves encapsulating pharmaceutical ingredients within tiny microcapsules that are then blended into a suspension before being filtered through an ultrafiltration membrane to produce a final solution. From there, the solution is ready for storage, further processing and dispensing as part of your finished dosage form. In this article, we will explore how submicron encapsulation technology can help you manufacture your products in ways that are cost-effective and also maintain compliance with both GMP regulations and current Good Manufacturing Practices (cGMP).

What is submicron encapsulation?

Submicron encapsulation refers to the process of forming microencapsulated ingredients into a suspension and then filtering them through ultrafiltration membranes. The encapsulation process takes place in a high-shear liquid chromatography (HSLC) system which, similar to a normal HPLC, separates ingredients from each other and from the ultrafiltration membrane by applying shear forces. The suspension is then ready for further processing and storage. SME is a perfect fit for many pharmaceutical companies looking to reduce manufacturing costs and increase their profits by scaling up their production of active ingredients. For example, many ingredients are best produced in bulk. Microencapsulation, however, does allow for the production of smaller batches that are then easily scaled up to meet the needs of a larger production run. Furthermore, many ingredients are best produced in granulation form. SME allows you to granulate your ingredients and then evenly mix them in the suspension before filtering through ultrafiltration membranes.

How does sub-micron encapsulation help with manufacturing?

Sub-micron encapsulation is a low-cost manufacturing process that allows you to produce pharmaceuticals in smaller batches, at lower costs. It’s a great alternative to GMP for companies looking to switch from manufacturing their products under GMP regulations (cGMP) to manufacturing in lower volumes and at lower costs. Additionally, the sub-micron method can also reduce the number of active ingredients in your finished pharmaceuticals, resulting in a less potent finished drug product.

Steps to take to manufacture using SME

It’s important to note that while sub-micron encapsulation can be an effective process for manufacturing pharmaceuticals, it’s also important to keep in mind that it’s no replacement for GMP or cGMP regulations. When using sub-micron encapsulation, you must adhere to manufacturing requirements such as using a certified manufacturing facility and adhering to Good Manufacturing Practices (cGMP). It’s important to understand that sub-micron encapsulation is not just a manufacturing process; it’s a manufacturing technology that can be used in conjunction with cGMP and GMP manufacturing as well. With that being said, there are a few steps you can take to get started with sub-micron encapsulation. First, confirm that your facility and equipment are suitable for the sub-micron method. Next, look at your finished drug product and its ingredients to determine if sub-micron encapsulation is the best method for manufacturing your finished pharmaceuticals. If it is, you can then move forward with sub-micron manufacturing.

Raphe Pharmaceutique Product engineering technology

In an effort to ensure that your manufacturing process is as seamless as possible, it’s important to consider developing a product engineering strategy. A product engineering strategy is designed to create processes that are as fluid and seamless as possible, while also preventing any issues that could arise as a result of re-engineering and harmonizing processes. Product engineering strategies can be applied while using any manufacturing method, but they are especially helpful when manufacturing pharmaceuticals via sub-micron encapsulation. While product engineering strategies may not be able to completely replace the sub-micron manufacturing method, they can be used to harmonize the sub-micron method with cGMP requirements and to create a process that is as seamless as possible.

Conclusion

Submicron encapsulation is a low-cost, quick, and scalable method for manufacturing a variety of ingredients and active pharmaceuticals. It’s also a great alternative to cGMP for companies looking to switch from manufacturing their products under GMP to manufacturing in lower volumes and at lower costs. However, it’s important to note that while sub-micron encapsulation is an effective process, it’s also important to keep in mind that it’s no replacement for GMP or cGMP regulations.

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When you manufacture an antibiotic, the quality and efficiency of the process are just as important as the raw materials, machinery, and people that make up your manufacturing facility. With limited space and challenging operating conditions, a reliable approach to manufacturing is key to success. In this article, we outline some strategies that can help you manage the manufacturing of azithromycin tablets more effectively.

Develop an accurate and complete master production schedule

The first step toward effective management is to develop an accurate and complete master production schedule. This schedule will help you understand how much raw material is required, the production flow, and the corresponding capacity. You will also determine the method of transfer between departments based on the raw material availability and the work in progress. In order to make sure that production is on schedule, you need to measure the actual flow of raw materials through your process. This way, you will know how much is left over and how much you need to buy. Likewise, you will be able to calculate the amount of capacity that you have. This will enable you to plan for equipment upgrades, scheduled maintenance, and workarounds if necessary.

Keep the manufacturing process under constant surveillance

As with all activities in a manufacturing facility, the production of azithromycin tablets is not risk-free. Every operation has the potential to cause a quality issue, which can have a significant impact on the finished product. Preventing issues early on will help to minimize the impact of these problems on the end product. This is because the quality issues will not have time to accumulate to the point where they affect the overall quality of the finished product. It is necessary to continually monitor the manufacturing process, with a particular focus on the following areas: – Raw materials – The microbiology of the raw materials and the fermentation process must be consistent. This is an area that manufacturers are particularly keen to monitor. Raw materials may be inconsistent due to poor hygiene, contamination from other products, or even as a result of equipment downtime. – Manufacturing environment – The surrounding environment within the manufacturing facility must be free of contaminants that could contaminate the finished product. This could include scale build-up on equipment or the presence of other chemicals that may be incompatible. – Operations – It is vital to pay close attention to the actions of all employees within the manufacturing facility. This includes their training and the processes that they carry out. It is important to conduct standardized audits to ensure that processes are carried out consistently.

Plan your equipment upgrades and maintenance accordingly

In order to effectively manage the process of manufacturing your products, it is important to keep up-to-date with the state of the equipment in your facility. Furthermore, it is essential to maintain the correct level of maintenance on these machines. A reliable approach to managing equipment upgrades and maintenance is to use aging programs. Aging programs enable you to keep track of the condition of equipment and predict the need for maintenance. This will help you to set up more efficient schedules for work to be carried out. It is also important to consider the full life cycle of your equipment when planning the level of maintenance required for it. It is common for manufacturers to only assess the condition of machinery once it has reached the end of its usable life. This can result in an important maintenance task being performed too late. Planning your maintenance accordingly will help to ensure that your machinery stays in the best possible condition.

Establish a comprehensive quality assurance program

Quality assurance programs are crucial when manufacturing antibiotics. They can help to ensure that each batch of products is consistent and safe to consume. Quality assurance programs should include each of the following: – Raw materials – The quality of raw materials used to produce the final product must be consistent. This may be as a result of purchasing raw materials from a reliable supplier or as a result of consistent microbiological quality within the fermentation process. – Manufacturing environment – The surrounding environment of the manufacturing facility must be free of contaminants that could contaminate the finished product. This could include scale build-up on equipment or the presence of other chemicals that are incompatible. – Operations – It is vital to pay close attention to the actions of all employees within the manufacturing facility. This includes their training and the processes that they carry out. It is important to conduct standardized audits to ensure that processes are carried out consistently.

Contact Raphe Pharmaceutique when you need help

If you are struggling to manage the manufacturing of your products, it may be time to contact Raphe Pharmaceutique. We have considerable experience in manufacturing issues and can provide advice and assistance on how to best manage these challenges.

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Tizanidine is a topical muscle relaxant used to relieve pain and muscle spasms. It works by blocking the action of acetylcholine in the nervous system, which reduces nerve signals and therefore decreases muscle contractions. Tizanidine is used topically as a cream or liquid solution that can be applied directly to the skin. The medication comes in both a transdermal (through the skin) formulation and an ointment (cream) form, with each available in different strengths for treating different types of symptoms. A transdermic formulation allows for absorption through the skin directly into the bloodstream, reducing side effects and maximizing effectiveness. If you are looking for more information on how tizanidine works and possible side effects of using it, continue reading below.

Mechanisms of Action

Tizanidine is a centrally acting muscle relaxant that works to reduce nerve signals and muscle contractions in the body. The medication binds to acetylcholine, a natural neurotransmitter that causes muscles to contract and nerves to send signals to the brain. Blocking the action of acetylcholine can alter nerve activity; the result is reduced muscle contractions and better control of muscles.

Side Effects and How to Avoid Them

Tizanidine is a safe medication that is generally well-tolerated. However, it may cause side effects while it is being used, and you can minimize their occurrence by following the medication instructions as closely as possible. -Significant side effects are rare, but they may include: -Headache – This may be mild or severe and is usually the result of your body’s inflammatory response to the medication. Headache is usually mild to moderate and goes away once you stop taking the drug. -Drowsiness – This is usually mild, but it can be more severe in older patients or those with a history of drug or alcohol use. Drowsiness is normal and can be minimized by taking the lowest dose that is effective for the symptoms you are treating. -Fatigue – This is also common and may be mild or moderate in severity. -Anxiety – Although this is not common, it is possible. You may experience mild anxiety as a side effect. -Altered mental state – This is also not common, but it could happen. It is usually mild or moderate in severity. -Blurred vision – This is usually mild and transient. -Dry mouth – This is also not common and occurs in association with many medications. It is usually mild and resolves on its own. -Other side effects are also possible, but they are rare.

Raphe Pharmaceutique-Your partner in pharmaceutical healing manufacturing

Raphe is a world leader in developing and producing proprietary topical and OSD formaulations for the healthcare and pharmaceutical industries. An innovative company with a strong research and development team, Raphe is committed to improving the lives of people through innovative solutions and high-quality products. As a fully integrated pharmaceutical manufacturing facility, Raphe provides complete process solutions that allow clients to meet their high product quality standards while also reducing their manufacturing costs. Raphe’s manufacturing facilities are ISO 9001/14001, QS Good Manufacturing Practices (GMP), and ISO 17011-compliant. In addition, the company is audited and certified to meet the stringent requirements of the U.S. Food and Drug Administration’s Deemed Risk Program.

Summary

Tizanidine is a muscle relaxant used to relieve pain and muscle spasms. It works by blocking the action of acetylcholine in the nervous system, which reduces nerve signals and therefore decreases muscle contractions. Tizanidine is available as a topical cream or liquid solution and comes in both a transdermal (through the skin) formulation and an ointment (cream) form. A transdermic formulation allows for absorption through the skin directly into the bloodstream, reducing side effects and maximizing effectiveness. Possible side effects of tizanidine topical include headache, drowsiness, fatigue, anxiety, and altered mental state. These side effects are usually mild and go away once you stop using the medication. Transdermal formulations are absorbed through the skin and may cause dry mouth. You may also experience blurred vision and increased heart rate while using this medication.

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Many people have had experience with topical pain relief cream. The question is: which one is the best? There are different types of topical pain relief creams on the market today. Some work by penetrating your skin, while others work through the barrier. If you’re looking for a topical pain relief cream that works fast and is easy to use, check out our review below of Topical Pain Relief Cream That Combines Ibuprofen and Indomethacin

How Does Raphe Pharmaceutique Ibuprofen and Indomethacin Pain Relief Cream Work?

First, let’s talk about how the topical pain relief cream works. It combines ibuprofen and indomethacin in a 1:1 ratio. The cream penetrates the skin, then binds to the pain receptors in your skin. This blocks the pain receptors, slowing down the transmission of pain signals. Ibuprofen is an anti-inflammatory, so it also helps reduce redness and swelling. These topical pain relief creams work by blocking pain signals from the nerves in your skin. The cream works by binding to pain receptors. When the pain receptors receive signals, they send a message to your brain, which then creates a feeling of pain. The pain cream then blocks those pain receptors, so no more signals are received. These topical pain relief creams can reduce pain associated with sore muscles, sprains, arthritis, joint pain, headaches, and more.

What’s the price of Ibuprofen and Indomethacin Combination Cream?

The products come in a 60g tube of 2.5% and 7.5% strength, so it will depend on which strength you choose. They also come in a roll-on bottle, a pump bottle, and a tube. The price of ibuprofen and indomethacin combination cream depends on the strength you choose. The 2.5% and 7.5% strengths are the most common strengths, and the prices depend on the quantity.

Pros of Ibuprofen and Indomethacin Cream

– Fast-Pain Relief – The topical pain relief cream works fast. If you’re in pain, you can apply the cream to the affected area. It penetrates the skin and then binds to the pain receptors in your skin, blocking pain signals. – Easy to Use – The topical pain relief cream is easy to apply. Just rub the cream on your skin to apply it, and then wash your hands. You can also apply the cream to your hands, feet, elbows, and knees to cover larger areas of your body. – Great for Sensitive Skin – These topical pain relief creams are great for sensitive skin. They can help soothe sensitive skin, reduce redness, and reduce swelling. – No Smell – These topical pain relief creams are odorless. – No Side Effects – These topical pain relief creams don’t have any side effects, so you can use them daily without worry.

Final Words

We hope that our review of topical pain relief cream has been helpful. If you want to try a topical pain relief cream, make sure to check out our list of the best topical pain relief creams. They’re all topical pain relief creams that work by penetrating the skin. Once we finish this list, you can compare and choose the one that works best for you. Good luck!

Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). This medicine reduces swelling and pain in the area where it is applied by blocking the action of certain natural substances known as cyclo-proteins or prostaglandins. As its name suggests, diclofenac works best when used to treat inflammation. It can be used to alleviate the symptoms of arthritis, such as pain and stiffness, by reducing inflammation in various tissues. The topical form of this medicine is preferred because it does not have to pass through the digestive tract first. Topical medicines are usually safe when used appropriately; however, this does not mean they are risk free. Although side effects are uncommon when using diclofenfac topically, there are still some things you should know about its uses and side effects before making a decision about whether or not it is right for you.

Raphe Pharmaceutique contract manufacturer Diclofenac Anti-inflammatory Cream

Raphe pharmaceutical industry is your partner in pharmaceutical healing manufacturing store brand Diclofenac non-steroidal anti-inflammatory drug (NSAID) topical creams and gels. This medicine reduces swelling and pain in the area where it is applied by blocking the action of certain natural substances known as cyclo-proteins or prostaglandins. As its name suggests, diclofenac works best when used to treat inflammation. It can be used to alleviate the symptoms of arthritis, such as pain and stiffness, by reducing inflammation in various tissues. The topical form of this medicine is preferred because it does not have to pass through the digestive tract first.

Uses of Diclofenac Anti-inflammatory Cream

Diclofenac is mainly used to treat inflammation in the joints, muscles, and certain skin conditions. It is also used to prevent blood clots after certain medical procedures, such as gastric bypass surgery, or to treat certain types of cancer, such as rheumatoid arthritis.

Side effects of Diclofenac Anti-inflammatory Cream

Many people do not experience any side effects when using diclofenac. However, some people may develop a rash, nausea, vomiting, diarrhea, irregular heartbeat, or drowsiness when taking this medicine. If you experience any of these symptoms, you should stop taking diclofenac and talk to your doctor immediately.

Dosage of Diclofenac Anti-inflammatory Cream

Diclofenac works best when taken every 12 hours. Swelling, pain, and inflammation should be treated for 48 hours after the injury has healed. In most cases, a dose is applied to the skin 2 times a day. Your doctor can recommend the best dosage for you.

Conclusion

Diclofenac is mainly used to treat inflammation in the joints, muscles, and certain skin conditions. It is also used to prevent blood clots after certain medical procedures or to treat certain types of cancer, such as rheumatoid arthritis. Topical medicines are usually safe when used appropriately; however, this does not mean they are risk free. Although side effects are uncommon when using diclofenac topically, there are still some things you should know about its uses and side effects before making a decision about whether or not it is right for you.

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Complete androgen insensitivity syndrome (CAIS) is a rare genetic condition in which a man has normal or functioning testes but either no or limited function of the androgen receptor. As a result, the man has little or no ability to produce testosterone, the male sex hormone that drives secondary sexual characteristics such as hair growth and facial features. The lack of functioning androgen receptors also prevents the man from having any type of genital development. CAIS affects approximately 1 in every 15 million males, making it one of the most common inherited genetic conditions. Individuals with CAIS usually do not live past infancy due to failure to develop external genitalia. While current medical treatments exist for lower urinary tract symptoms related to incomplete androgen insensitivity syndrome, there is currently no cure for this disease.

Myovant Sciences and Pfizer Announce FDA Approval of MYFEMBREE® for the Management of Moderate to Severe Pain Associated With Endometriosis

Endometriosis is a common condition in which tissue similar to endometrial tissue is found outside of the uterus, most commonly on the ovaries, bowel, or other pelvic organs. In addition to being painful, endometriosis is associated with increased risk of certain types of cancers. The FDA approval of MYFEMBREE® as a treatment for moderate to severe chronic pelvic/endometriosous pain associated with endometriosis was based on a global Phase III clinical trial that included women with moderate to severe chronic pelvic/endometriosous pain associated with endometriosis. In the primary endpoint, MYFEMBREE® met statistical significance as an improvement in pain (decrease of at least 50% from baseline) compared to placebo over 24 weeks. MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women.

What is endometriosis?

Endometriosis is a common condition in which tissue similar to endometrial tissue is found outside of the uterus, most commonly on the ovaries, bowel, or other pelvic organs. In addition to being painful, endometriosis is associated with increased risk of certain types of cancers. Endometriosis is often difficult to diagnose due to its similar-appearing signs and symptoms (such as painful periods) with other conditions that are unrelated to endometriosis. These other conditions may, in some cases, be more difficult to diagnose than endometriosis. Typically, the diagnosis of endometriosis is made after confirmation of a finding on laparoscopy, such as endometriosis lesions on the ovaries, bowel, or pelvic/perineal areas.

How does Myovant Sciences’ MYFEMBREE® work?

MYFEMBREE® works by releasing oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women. MYFEMBREE® is designed to be implanted subdermally, releasing oxytocin over a period of 4 to 6 weeks. MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women. MYFEMBREE® is designed to be implanted subdermally, releasing oxytocin over a period of 4 to 6 weeks. MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women. MYFEMBREE® is designed to be implanted subdermally, releasing oxytocin over a period of 4 to 6 weeks. MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women. MYFEMBREE® is designed to be implanted subdermally, releasing oxytocin over a period of 4 to 6 weeks.

Benefits of MYFEMBREE® in pain management

– MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women. MYFEMBREE® is designed to be implanted subdermally, releasing oxytocin over a period of 4 to 6 weeks. – MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women. MYFEMBREE® is designed to be implanted subdermally, releasing oxytocin over a period of 4 to 6 weeks. – MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women. MYFEMBREE® is designed to be implanted subdermally, releasing oxytocin over a period of 4 to 6 weeks. – MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that has been shown in several human studies to improve symptoms of chronic pelvic/endometriosous pain associated with endometriosis. MYFEMBREE® is the first treatment for endometriosis that targets the source of pelvic/endometriosous pain, providing a better treatment alternative for these women. MYFEMBREE® is designed to be implanted subdermally, releasing oxytocin over a period of 4 to 6 weeks. – MYFEMBREE® is a subcutaneous implant containing subdermal pellets that are designed to release oxytocin, a naturally-occurring hormone in the body that

They see the world as an intellectual puzzle to be solved, taking in everything around them via their own inward-looking scrutiny of theory. They analyse logical concepts and problems to determine the world around them, and they are drawn to logical systems. Because INTJs are less drawn to the unpredictable nature of other people’s emotions, they typically prefer to associate with like-minded people.

Intuitive thinking and complex problems are favourite INTJ topics. They perceive the world by studying the principles underlying what they see, and their focus is inward, on their own intellectual investigation of the world around them. INTJs want to study logical systems, and this is why they like people who are more spontaneous than others. INTJs prefer to associate with individuals who interest them intellectually, rather than those whom they like.

Discovering New Treatment Strategies for Sickle Cell Disease

In the clinical research process, a large number of patients participate in studies that investigate an innovative treatment or approach. Cancer drugs, for instance, and COVID-19 vaccines, have been produced as a result of decades-old research procedures.

When researchers want to investigate a rare disease, one that affects a small proportion of people, what happens if those who are affected by it are not willing to participate due to social difficulties, under-representation, or a lack of trust in the medical system?

There are several issues with sickle cell disease that are listed below.

SCD), a painful, rare genetic blood disorder typically discovered in infancy, and particularly sickle cell anemia, one of four common types of SCD that is usually regarded as the most serious. 100,000 Americans are affected by the condition, 70 percent of whom are people of colour. In spite of improving outcomes, sickle cell disease still has roadblocks due to some of the peculiar healthcare obstacles minority communities have faced and continue to do so.

Working with patients and patient advocates, the medical research community is able to work toward more effective treatments for this hard-to-cure disease.

Why Sickle Cell Disease Phase I/II Clinical Trials Are Difficult

Sickle cell disease poses many unique challenges for patients interested in participating in clinical research. In particular, the frequency of required research site visits can be challenging for some patients—all the more so amidst COVID-19 and its underlying social disparities.4

“When you think about the time and expense involved in a clinical trial, plus the fact that sickle cell disease often is discovered when a patient is young, it’s easy to see why families might have a harder time handling those burdens,” says Steven Arkin, Pfizer’s Head of Rare Hematology Clinical Research.

Many SCD patients are of African descent, but many physicians are not. This can make it more difficult to recruit or engage potential study participants.

The Tuskegee syphilis experiments, in which African Americans were unwitting subjects, contributed to causing people of color to distrust the medical community.6 However, mistrust is not just a result of historical pain. Modern-day biases, even when unconscious, can continue to perpetuate mistrust, such as when some healthcare providers dismiss or downplay patients’ descriptions of their pain.7

Quintissa Peake, who was diagnosed with sickle cell disease at 11 months old, has experienced these biases first-hand. Growing up with frequent sickle cell crises, including uncontrolled swelling in her hands and feet as well as lingering pain in her arms and legs, Peake has been no stranger to symptoms of this disease. Unfortunately, not all of her care providers have been as familiar with the condition.

“The pain of a sickling crisis is often met with stigma from members of the public,” says Peake, now 40. “When we are in need of medical care, we go to the emergency room. However, once we are there, we may be treated like drug addicts.”

Many patients have come to resent the medical community for setting back clinical research by unreasonably refusing to participate in trials.

Advocacy helps to educate, build confidence and boost interest in clinical research, says courtside.

Patients Wanting to Be Heard During Their Treatment.

Advocates, such as Beverly Francis-Gibson, facilitate two-way communications between patients, drug companies, researchers, and healthcare professionals to gather patient opinions and requests.8 They also use social media, email, and other channels to facilitate conversations.

Francis-Gibson says she aims to provide patients with an understanding and education of clinical trials if they are interested in participating, and she also works with the pharmaceutical industry to ensure they hear from patients before starting their trial. Her SCD makes her particularly sensitive to patients’ concerns, and she wants to be a trusted person who can help them.

Patient advocates such as Mariah Kelly of Pfizer’s patient advocacy team, on the other side of that conversation, work to connect and partner with the pharmaceutical industry. They share trial details and field patient questions.

According to Kelly, Pfizer’s patient advocacy director, working closely with sickle cell patients and their care providers in drug discovery and development is a key part of addressing their needs. Patient advocacy work is vital in gathering important information that can be used to build and support a meaningful sickle cell program. The biggest challenge we face is listening and learning about the realities of what patients are going through and how they feel. Only advocates and patients can give us this information.

“Sickle cell disease, in particular, needs medical research breakthroughs to make progress.”

After receiving multiple blood transfusions during college, Peake became involved in her local blood bank and volunteered. This has enabled her to express herself as a “sickle cell survivor.”

“There are now so many opportunities to share my story on social media and locally,” she says, “thanks to technology. That is why I decided to become an advocate. It helps us build a community of warriors, so we don’t feel so lonely.” Because she was the only family member with Crohn’s disease as a child, she says, “Advocacy gives us a sense of community.”

Peake and others have gained strength through hard times as well as new scientific frontiers in sickle cell treatments thanks to the emotional support that advocates have provided. Many therapies might never have existed if the barriers and reach of clinical trials had not been broken through.

“As I’ve aged, the treatment options for sickle cell have definitely expanded,” Peake says. “When I was a child, doctors told my family that I would not live past adolescence. Yet here I am, and look at all of us.”

“The progress we’ve made is just the beginning,” says Arkin. “As we continue to build on it, incorporating patient voices and experiences thoughtfully and intentionally into clinical trial design is critical,” he says. “It allows the scientific community to evaluate new approaches for treating this devastating disease and provides us all with every reason to be optimistic about improved treatment options.”

The BeSafeRx app can help you identify and avoid fraudulent online pharmacies. How do you tell if an online pharmacy is operating legally?

Have you ever thought about buying your medications from an online pharmacy or another website?

Be careful when purchasing medicines online. There are several legitimate pharmacy websites that offer convenience, privacy, and safeguards for purchasing medicines.

The U.S. Food and Drug Administration warns that there are many rogue online pharmacies that sell prescription medicines at deeply discounted prices, often without requiring a valid prescription. These pharmacies sell unapproved or counterfeit medicines outside the safeguards followed by licensed pharmacies.

The Canadian flag may be seen prominently on these rogue websites, but they may be run by criminals from another country and have nothing to do with Canada. Purchases from these sites may also be dangerous and may harm your health.

Using the FDA’s BeSafeRx, you can identify and avoid fake online pharmacies. How can you tell if an online pharmacy is operating legally?

A warning sign of a rogue online pharmacy is the presence of fake or false testimonials and reviews.

Be careful of online pharmacies that:

These pharmacies often sell medicines that may be dangerous because: They may contain impurities.

The active ingredient is what makes the medicine work for the illness or condition it is intended to treat. It causes one of the following three situations: 1) the medicine works as intended, 2) the medicine has no effect, or 3) the medicine causes dangerous side effects.

It is possible that the medicine you are taking was not stored properly, and as a result, it may not work well to treat your condition.

Identify Online Pharmacies That Are Legit and Secure

To avoid getting ripped off, you should look for signs that an online pharmacy is reputable. Look for these signs:

The National Association of Boards of Pharmacy (NABP) Verified Internet Pharmacy Practice SitesTM Seal, also known as the VIPPS® Seal, is a trustworthy way to check on a website. It means that it complies with state pharmacy regulations as well as other NABP requirements. You can find legitimate pharmacies that carry the VIPPS® seal on the VIPPS website.

Be careful when shopping online.

As for autumn, another bivalent candidate for the mRNA-1273.214 bivalent booster is also being developed, but only the BA.4/5 clinical trial demonstrated significantly higher titers against the strain.

The vaccine is based on a version of the spike protein that the companies hope will offer better and broader protection against the virus.

A new version of the COVID-19 vaccine is being studied in a phase 2 trial jointly run by Pfizer and BioNTech. It is hoped that it will better protect against the virus.

The Pfizer-BioNTech COVID-19 vaccine, BNT162b5, includes RNAs encoding ‘enhanced’ prefusion spike proteins for the SARS-CoV-2 wild-type strain and an Omicron variation, in an attempt to increase the magnitude and breadth of the immune response.

Around 200 participants aged 18 to 55 will be recruited for a US-based study in which the vaccine candidate will be evaluated. Following an enrollment period, participants will be randomly assigned to subgroups based on the number of months since their last dose. A placebo will not be used in the study.

The companies said BNT162b5 is the first of multiple vaccine candidates with an enhanced design, representing their long-term COVID-19 vaccine strategy to overcome the relatively short-lived immune response seen with their first-generation vaccine, BNT162b2.

The trial’s commencement comes as vaccine developers are beginning to develop new versions of their vaccines in response to Omicron, following the US Food and Drug Administration’s (FDA) recommendation to continue developing Omicron-targeting formulations, with the aim of making them available in autumn this year.

Pfizer and BioNTech submitted Omicron-adapted bivalent COVID-19 vaccine to the European Medicines Agency (EMA) earlier in July, based on the BA.1 sub-lineage.

The Omicron-adapted bivalent vaccine candidate produced superior immune responses against Omicron BA.1 in phase 2/3 tests following positive results from a phase 2/3 trial.

Moderna announced positive data in July for its bivalent BA.1 booster candidate, mRNA-1273.214, showing a significantly higher neutralising antibody response against Omicron subvariants BA.4 and BA.5 compared to mRNA-1273, regardless of prior infection status or age.

However, the mRNA-1273.214 bivalent booster is the only candidate that has demonstrated significantly higher titers against the BA.4/5 strain in a clinical trial.

Our journey to sustainable growth at Merck, as a consumer-centric, multi-functional, and holistic innovation process and marketing approach, depends on a consumer-centric, multi-functional, and holistic innovation process and marketing approach. We look forward to taking this forward in 2015 and beyond.

Consumers are gravitating to wellbeing and avoiding sickness in a big way these days. As a consequence, the OTC industry is experiencing a lot of change. The OTC sector is expanding much faster than prescription drugs, and this is driving major transformation. Prescription drugs are losing ground to OTC brands as healthcare companies concentrate on these types of merchandise. The OTC industry is worth more than $100 billion today, and it will grow at a rate of 4% over the next 10 years. Allergen, wellness, gastrointestinal, analgesics, dermatologicals, and cold and cough medicine are just a few of the sectors that are enjoying strong growth. Companies like these are managing profits of over 20% on their products.

The top companies control nearly a quarter of the OTC market. M&A activity has had an impact on the commercial environment, as is the case with the recent joint venture between GSK and Novartis. Due to the fragmented nature of the sector, it is likely that M&A activity will be prevalent in 2015. FMCG companies that have traditionally focused more on the OTC segment are currently stepping up their efforts to enter the sector. Reckitt Benckiser, for example, is refocusing its efforts on ‘health, hygiene, and home’ in response to customer demand.

The changing landscape has provided Merck Consumer Health with the opportunity to steadily increase our market share and position, three key factors being responsible.

We are excited about the upcoming 350th anniversary celebrations of the Merck Group, which gives us the flexibility to respond to market pressures, but is not affected by them. In 2018, we will celebrate our history as a company.

In addition, we have prioritised building our market position through a well-defined business strategy. We have achieved $1bn in sales, while operating in fast-growing emerging markets and delivering consistent top and bottom line growth, with profit and margins comparable to leading competitors in the industry.

Consumer Health has established its market position by building on the market expertise of other Merck businesses.

To drive growth and change in the Consumer Health business, Merck has used the incorporation of new brands, the transfer of Merck Serono’s operations, to grow operations. Merck Serono’s new products have contributed to this success. Our strategy has been to establish a minimum market share of 3 percent and a minimum of 3 leading consumer brands in every market in which we compete. As a brand business, Consumer Health is driven by Neurobion, Dolo-Neurobion, Bion, Seven Seas, Nasivin, and Femibion products. In 2014, Neurobion, Seven Seas, and Femibion grew the most, and Consumer Health was Merck’s fastest-growing business.

Bion, Nasivin, and Seven Seas Perfect 7 are key brands which Merck Consumer Health has produced in the last year to expand organic sales. Merck Consumer Health is expecting short- to mid-term organic growth through innovations to its existing key brands, particularly the new Nasivin Mentholfresh launch in Germany, Bion Equilibre launch in France, and the debut of Seven Seas Perfect 7 in the UK. Geographic expansion will focus on key products in key markets, such as Bion in Brazil. In the longer term, Merck Consumer Health may integrate new products. Merck Consumer Health aims to cross the billion-dollar income barrier through the systematic growth of its current product portfolio.

At Merck, the Consumer Health business is aiming for sustainable growth by utilising a multi-functional, holistic and consumer-centric innovation process and marketing strategy. We are looking forward to continuing this in 2015 and beyond.